Paymaster N J
Br J Anaesth. 1976 Jun;48(6):599-605. doi: 10.1093/bja/48.6.599.
In a single-blind study of several doses of a new hexahydroazepine analgesic, meptazinol, in 45 patients recovering from major abdominal surgery, there was a dose-related significant analgesic effect from i.m. doses exceeding 50 mg. Pain relief was maximal at the end of 1 h and the duration of effect of the 100-mg dose was approximately 5 h. There was a good correlation between pain relief assessed by the patient, by the physician, and indirectly by pulmonary function tests. Heart rate and arterial pressure were not affected by meptazionol. There were no abnormal biochemical or haematological findings and the only side-effect was vomiting in a few patients receiving multiple doses of the drug.
在一项针对45名接受腹部大手术康复患者的单盲研究中，研究了几种剂量的新型六氢氮杂卓镇痛药美普他酚。肌肉注射剂量超过50毫克时，存在剂量相关的显著镇痛效果。疼痛缓解在1小时末达到最大，100毫克剂量的作用持续时间约为5小时。患者、医生评估的疼痛缓解与通过肺功能测试间接评估的疼痛缓解之间存在良好的相关性。美普他酚对心率和动脉压无影响。没有异常的生化或血液学检查结果，唯一的副作用是少数接受多次给药的患者出现呕吐。
