Pemberton R M, Malaquias L C, Falcao P L, Silveira A M, Rabello A L, Katz N, Amorim M, Mountford A P, Coffman R L, Correa-Oliveira R
Department of Biology, University of York, United Kingdom.
Trop Geogr Med. 1994;46(4 Spec No):247-54.
This report describes parallel studies examining T cell and cytokine responses to Schistosoma mansoni in mice and man. The prevalence of IFNg production amongst murine (C57BL/6) T cell lines and clones, plus good DTH reactivity by IFNg-secreting clones, highlights the predominance of the Th1 response in the pulmonary immunity characteristics of the murine irradiated vaccine model. In human studies, effects of anti-cytokine antibodies on the proliferation of PBMC from human patients to various soluble schistosome antigen preparations have been examined. Data suggest that both Th1 (against early antigens) and Th2 (against late antigens) responses are present. A role for IL-10 is highlighted in chronic intestinal, but not acute or chronic hepatosplenic patients, as a downregulator of responses which are associated with morbidity and are against late stage antigens.
本报告描述了在小鼠和人类中检测针对曼氏血吸虫的T细胞和细胞因子反应的平行研究。在小鼠（C57BL/6）T细胞系和克隆中，IFNg产生的普遍性，以及分泌IFNg的克隆具有良好的迟发型超敏反应性，突出了Th1反应在小鼠辐照疫苗模型肺部免疫特征中的主导地位。在人体研究中，已经检测了抗细胞因子抗体对人类患者外周血单核细胞（PBMC）对各种可溶性血吸虫抗体制剂增殖的影响。数据表明，Th1（针对早期抗原）和Th2（针对晚期抗原）反应均存在。IL-10在慢性肠道患者而非急性或慢性肝脾患者中作为与发病相关且针对晚期抗原的反应的下调因子，其作用得到了强调。
