Larsen K, Tos M
ENT Clinic, Jernbanegade Esbjerg, Copenhagen, Denmark.
Acta Otolaryngol. 1994 Sep;114(5):556-9. doi: 10.3109/00016489409126104.
A follow-up study on 180 patients treated for the first time for nasal polyps was performed. The follow-up period was from 1 to 8 years with a median of 57 months. The majority of patients had postoperative topical steroid treatment. 65.6% of patients had one polypectomy, 17.8% had two polypectomies, 10% had 3, 2.8% had 4, and 3.9% of patients had 5-10 polypectomies performed during the follow-up period. Patients without asthma, acute recurrent or chronic sinusitis, acetylsalicylic acid intolerance, or allergy had fewer polypectomies and less topical steroid treatment than patients with these characteristics. The recurrence profile between the first and second polypectomy described with the life-table method showed a slow decline in the number of patients with only one polypectomy. The time span needed before significant clinical symptoms occurred after the first polypectomy indicates that not all primary polyp patients are prone to recurrence. Nasal polyps is probably a manifestation of different clinical and aetio-pathogenetic entities. Further identification of such entities is needed to improve treatment strategy.
对180例首次接受鼻息肉治疗的患者进行了一项随访研究。随访期为1至8年，中位数为57个月。大多数患者术后接受局部类固醇治疗。65.6%的患者接受了一次息肉切除术，17.8%的患者接受了两次息肉切除术，10%的患者接受了3次，2.8%的患者接受了4次，3.9%的患者在随访期间接受了5至10次息肉切除术。与有哮喘、急性复发性或慢性鼻窦炎、阿司匹林不耐受或过敏的患者相比，没有这些特征的患者息肉切除术较少，局部类固醇治疗也较少。用寿命表法描述的首次和第二次息肉切除术之间的复发情况显示，仅接受一次息肉切除术的患者数量缓慢下降。首次息肉切除术后出现明显临床症状所需的时间跨度表明，并非所有原发性息肉患者都易于复发。鼻息肉可能是不同临床和病因-发病机制实体的一种表现。需要进一步识别这些实体以改进治疗策略。
