Savini L, Massarelli P, Chiasserini L, Pellerano C, Bruni G
Dipartimento Farmaco Chimico Tecnologico, Facoltà di Farmacia, Università Banchi di Sotto, Siena, Italy.
Farmaco. 1994 Oct;49(10):633-9.
Several 1-[quinolyl(4)]-1,2,3-triazoles were synthesized by 1,3-dipolar cycloaddition of 4-azidoquinolines with activated methylene compounds. The synthesized compounds, tested for antiinflammatory and analgesic activities, resulted moderately active as antiinflammatories, but with a very interesting analgesic activity, sometimes higher than that of indomethacin, used as reference drug. Some of the triazole derivatives were evaluated also as antimicrobial, but none of them exhibited activity.
