MHC II类限制性肿瘤抗原以及CD4+ T细胞在癌症免疫治疗中的作用。
MHC class II restricted tumor antigens and the role of CD4+ T cells in cancer immunotherapy.
作者信息
Topalian S L
机构信息
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
Curr Opin Immunol. 1994 Oct;6(5):741-5. doi: 10.1016/0952-7915(94)90078-7.
PMID:7826529
Abstract
Recent studies in human and murine systems suggest a central role for CD4+ T cells in initiating, effecting and maintaining anti-tumor immunity. Characterization of the tumor-associated antigens recognized by CD4+ T cells may prove critical to the success of cancer immunotherapy strategies.
摘要
近期在人类和小鼠系统中的研究表明，CD4+ T细胞在启动、实现和维持抗肿瘤免疫中发挥核心作用。对CD4+ T细胞识别的肿瘤相关抗原进行表征，可能对癌症免疫治疗策略的成功至关重要。
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