Wu T C
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Curr Opin Immunol. 1994 Oct;6(5):746-54. doi: 10.1016/0952-7915(94)90079-5.
Human papillomaviruses (HPVs) have been associated with benign and malignant epithelial proliferations in either skin or mucosa. Two HPV oncogenic proteins, E6 and E7, are important in the induction and maintenance of cellular transformation and are co-expressed in the majority of HPV-containing carcinomas. Therefore, vaccines targeted to these proteins may provide an opportunity to prevent and treat HPV-associated malignancies. The encouraging results from recent experimental vaccination systems in animal models suggest that continued exploration in these systems might lead to trials on human subjects and might allow us to prevent HPV infection or control its potentially life-threatening consequences.
人乳头瘤病毒（HPV）与皮肤或黏膜的良性及恶性上皮增生有关。两种HPV致癌蛋白E6和E7在细胞转化的诱导和维持过程中起重要作用，并且在大多数含HPV的癌中共同表达。因此，针对这些蛋白的疫苗可能为预防和治疗HPV相关恶性肿瘤提供契机。近期动物模型实验性疫苗接种系统取得的令人鼓舞的结果表明，在这些系统中持续开展探索可能会促成人体试验，并可能使我们预防HPV感染或控制其潜在的危及生命的后果。
