急性心肌梗死后数月急性洋地黄化的血流动力学效应。
Hemodynamic effects of acute digitalization several months after acute myocardial infarction.
作者信息
Ressl J, Jandová R, Jebavý P, Kasalický J, Widimský J
出版信息
Cardiology. 1975;60(6):321-8. doi: 10.1159/000169732.
Left ventricular function was investigated at rest and during exercise by heart catheterization in 15 patients 3-5 months after acute myocardial infarction. The effect of 1 mg digoxin i.v. in ten patients was correlated to placebo (saline solution) in five patients. A significant decrease of the left ventricular enddiastolic pressure, increase of left ventricular systolic ejection fraction and a shift of the left ventricular function curve to left upwards was found after digoxin with no changes in the placebo group. This beneficial effect of acute digitalization in patients convalescing from uncomplicated myocardial infarction without clinical signs of manifest heart failure could have therapeutic implication.
在15例急性心肌梗死后3至5个月的患者中，通过心导管检查对静息和运动状态下的左心室功能进行了研究。10例患者静脉注射1毫克地高辛，5例患者注射安慰剂（生理盐水），比较二者效果。注射地高辛后，左心室舒张末期压力显著降低，左心室收缩射血分数增加，左心室功能曲线向左上方移位，而安慰剂组无变化。对于无明显心力衰竭临床症状的单纯性心肌梗死康复期患者，急性洋地黄化的这种有益作用可能具有治疗意义。
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