Singewald N, Schneider C, Philippu A
Department of Pharmacology and Toxicology, University of Innsbruck, Austria.
Neuroreport. 1994 Sep 8;5(14):1709-12. doi: 10.1097/00001756-199409080-00005.
The locus coeruleus (LC) of anaesthetized rats was superfused with artificial cerebrospinal fluid through a push-pull cannula and the release of the amino acids gamma-aminobutyric acid (GABA), taurine and arginine was determined in the superfusate. Increases in blood pressure (BP) induced either by intravenous infusions of noradrenaline and phenylephrine or by blood injection enhanced the release of GABA in the LC. Decreases in BP elicited by intravenous infusion of sodium nitroprusside or by haemorrhage decreased the GABA release rate. The BP changes did not influence the release rates of taurine and arginine. These findings demonstrate that GABA release in the LC is modified by cardiovascular impulses and suggest that GABAergic neurones modulate LC activity in response to disturbances in BP homeostasis.
通过推挽式套管向麻醉大鼠的蓝斑（LC）灌注人工脑脊液，并测定灌流液中氨基酸γ-氨基丁酸（GABA）、牛磺酸和精氨酸的释放量。静脉输注去甲肾上腺素和去氧肾上腺素或注射血液诱导的血压（BP）升高增强了蓝斑中GABA的释放。静脉输注硝普钠或出血引起的血压降低降低了GABA的释放速率。血压变化不影响牛磺酸和精氨酸的释放速率。这些发现表明，心血管冲动可改变蓝斑中GABA的释放，并提示GABA能神经元可响应血压稳态的干扰来调节蓝斑活动。
