Haruta H, Kamishita T, Hicks T P, Takahashi M P, Tsumoto T
Department of Neurophysiology, Osaka University Medical School, Suita, Japan.
Neuroreport. 1994 Sep 8;5(14):1829-32. doi: 10.1097/00001756-199409080-00036.
Long-term potentiation (LTP) and long-term depression (LTD), often used as essential components in synaptic models for learning, memory and forgetting, can be produced in cortical tissue by repetitive activation of neural pathways under different stimulus conditions. The involvement of metabotropic glutamate receptors (mGluRs) has been postulated to be necessary for the establishment of either or both forms of synaptic plasticity in hippocampus. The recent introduction of a specific antagonist for mGluRs, (+/-)-alpha-methyl-4-carboxyphenylglycine, prompted the investigation of the respective involvement of this receptor population in the induction of LTP and LTD in visual cortex of the rat in vitro. The results suggest the critical involvement of mGluRs in producing LTD but not LTP.
长期增强作用（LTP）和长期抑制作用（LTD）常被用作学习、记忆和遗忘的突触模型中的关键组成部分，在不同刺激条件下通过神经通路的重复激活可在皮质组织中产生。代谢型谷氨酸受体（mGluRs）的参与被认为是海马体中建立一种或两种形式的突触可塑性所必需的。mGluRs特异性拮抗剂（±）-α-甲基-4-羧基苯基甘氨酸的近期问世，促使人们研究该受体群体在体外大鼠视觉皮质中LTP和LTD诱导过程中的各自作用。结果表明，mGluRs在产生LTD而非LTP过程中起关键作用。
