Beets G, Penninckx F, Schiepers C, Filez L, Mortelmans L, Kerremans R, Aerts R, De Roo M
Department of Abdominal Surgery, University Clinic Gasthuisberg, Catholic University of Leuven, Belgium.
Br J Surg. 1994 Nov;81(11):1666-70. doi: 10.1002/bjs.1800811136.
To assess the clinical value of whole-body positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) in recurrent colorectal cancer, 35 patients were studied: 15 had resectable liver metastases, one a resectable lung metastasis, eight resectable pelvic recurrence, eight a presacral mass with equivocal findings on imaging, and three increasing serum levels of carcinoembryonic antigen (CEA) without clinical or radiological signs of recurrent disease. PET affected management decisions in seven of 16 patients with metastatic disease. In one of eight patients with pelvic recurrence demonstrated by computed tomography (CT), PET detected unknown pulmonary metastases. In five of eight presacral masses with equivocal CT findings, PET was correct and unexpected distant metastases were detected in one of these patients. In two of three patients with increasing CEA levels and normal pelvic CT findings, pelvic recurrence was identified. Overall, whole-body PET affected management in 14 patients. PET is a valuable tool for staging local recurrence and metastatic disease.
为评估[18F]氟脱氧葡萄糖（FDG）全身正电子发射断层扫描（PET）在复发性结直肠癌中的临床价值，对35例患者进行了研究：15例有可切除的肝转移，1例有可切除的肺转移，8例有可切除的盆腔复发，8例骶前有肿块且影像学表现不明确，3例癌胚抗原（CEA）血清水平升高但无复发疾病的临床或放射学征象。PET影响了16例转移性疾病患者中7例的治疗决策。在计算机断层扫描（CT）显示的8例盆腔复发患者中，PET检测到1例未知的肺转移。在CT表现不明确的8例骶前肿块患者中，5例PET诊断正确，其中1例检测到意外的远处转移。在3例CEA水平升高且盆腔CT检查正常的患者中，2例发现盆腔复发。总体而言，全身PET影响了14例患者的治疗。PET是评估局部复发和转移性疾病分期的有价值工具。
