Mironov V, Hritz M A, LaManna J C, Hudetz A G, Harik S I
Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH.
Brain Res. 1994 Oct 10;660(1):73-80. doi: 10.1016/0006-8993(94)90840-0.
We performed 3-dimensional studies of vascular casts of the microvasculature of the cerebral cortex of rats that were exposed to three weeks of hypobaric hypoxia and of control rats. Scanning electron microscopy of the casts gave the qualitative impression of increased vascularity of the cerebral cortex, particularly the deeper layers, in hypoxic rats. Quantitative analysis of capillary segment lengths revealed a significant shift in the frequency distribution to longer lengths (from 77 +/- 8 to 90 +/- 14 microns) in the deep, but not in the superficial, layers of the cerebral cortex of hypoxic rats. These findings agree with previous results reporting increased capillary density in the brain after exposure to prolonged hypobaric hypoxia and suggest that capillary segment elongation plays a role in the increased capillary density in the deeper layers of the cerebral cortex.
我们对暴露于三周低压缺氧环境的大鼠及对照大鼠的大脑皮质微血管铸型进行了三维研究。铸型的扫描电子显微镜检查显示，缺氧大鼠大脑皮质，尤其是深层的血管有增多的定性印象。对毛细血管段长度的定量分析表明，缺氧大鼠大脑皮质深层而非浅层的频率分布有显著变化，向更长的长度偏移（从77±8微米变为90±14微米）。这些发现与先前报道的长期低压缺氧暴露后大脑毛细血管密度增加的结果一致，并表明毛细血管段延长在大脑皮质深层毛细血管密度增加中起作用。
