Dahl M, Ahlsten G, Carlson H, Ronne-Engström E, Lagerkvist B, Magnusson G, Norrlin S, Olsen L, Strömberg B, Thuomas K A
Department of Paediatrics, University Children's Hospital, Uppsala, Sweden.
Dev Med Child Neurol. 1995 Jan;37(1):30-40. doi: 10.1111/j.1469-8749.1995.tb11930.x.
The aim of this study was to characterize the neurological dysfunction above the cele level in children with spina bifida cystica. 22 neonates were investigated prospectively to a median age of three years. Before primary closure of the spinal malformation and at three and 18 months of age, MRI and inspection of vocal cord function were performed. The children were also assessed by a physical therapist at 12 and 24 months, 19 children had a Chiari malformation, 18 children developed neurological dysfunction above the cele level. Children with signs of isolated motor impairment stabilized or improved during the second year. Six children developed severe functional impairment of respiration, feeding and motor performance within the first three months of life. Severe neurological signs/symptoms were associated with myeloschisis, clinical signs of a tethered cord and recurrent periods of shunt dysfunction.
本研究的目的是描述脊柱裂脊膜膨出患儿膨出水平以上的神经功能障碍。对22例新生儿进行前瞻性研究，至中位年龄3岁。在脊柱畸形一期闭合前以及3个月和18个月大时，进行了MRI检查和声带功能检查。这些儿童还在12个月和24个月时接受了物理治疗师的评估，19名儿童患有Chiari畸形，18名儿童出现膨出水平以上的神经功能障碍。有孤立运动障碍体征的儿童在第二年病情稳定或有所改善。6名儿童在出生后的前三个月内出现了呼吸、喂养和运动功能的严重损害。严重的神经体征/症状与脊髓裂、脊髓栓系的临床体征以及分流功能障碍的复发期有关。
