大肠杆菌肠毒素对大分子吸收的影响。
Effect of Escherichia coli enterotoxins on macromolecular absorption.
作者信息
Verma M, Majumdar S, Ganguly N K, Walia B N
机构信息
Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Gut. 1994 Nov;35(11):1613-6. doi: 10.1136/gut.35.11.1613.
Abstract
Macromolecular absorption of gliadin, a wheat protein and alpha lactalbumin, a milk protein was evaluated in control and Escherichia coli enterotoxin (heat-stable, heat-labile, and both heat-stable and heat-labile enterotoxin) treated mice. The peak concentration of gliadin and lactalbumin was two hours and three hours after their ingestion, respectively. There was also a significant increase (p < 0.01) in the absorption of both the proteins in all the three toxin treated groups compared with the control group. These results suggest that intestinal permeability and macromolecular absorption changes after E coli infection.
摘要
在对照小鼠和经大肠杆菌肠毒素（热稳定型、热不稳定型以及热稳定和热不稳定型肠毒素）处理的小鼠中，评估了麦醇溶蛋白（一种小麦蛋白）和α-乳白蛋白（一种乳蛋白）的大分子吸收情况。麦醇溶蛋白和乳白蛋白的峰值浓度分别在摄入后两小时和三小时出现。与对照组相比，所有三个毒素处理组中这两种蛋白质的吸收也均显著增加（p < 0.01）。这些结果表明，大肠杆菌感染后肠道通透性和大分子吸收会发生变化。
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