Ramasamy S, Balakrishnan K, Pitchappan R M
Nilgiris Adiwasi Welfare Association Hospital, Kotagiri.
Indian J Med Res. 1994 Nov;100:242-5.
A total of 1377 tribals, comprising Irulas (536), Paniyas (196), Kurumbas (87), Mullukrurumbas (156) and Soligas (402), living in the Nilgiris, Tamil Nadu, India were studied for sickle cell trait between 1981-85. Patients attending various tribal clinics at Arayure, Kozhikarai, Kothagiri and Biligiri Rengan hills for various ailments were screened at random by solubility test and by acetate paper electrophoresis, if required. HbAS carrier frequency was 30-37.8 per cent in all the tribals studied except Kurumbas (19.5%). The frequency of carriers were more (37.8%) on the western part of Nilgiris (Nedungode, Kappala and adjoining regions) than the eastern part (30%). Further, the prevalence of carriers was higher (47-49%) in the 10-19 yr age group amongst Paniyas and Mullukurumbas living in the western part of Nilgiris. An episodic, epidemic of malaria so rampant during the early part of this century in the western parts of Nilgiris might have eliminated many children with HbAA and hence the higher frequency of HbAS in this particular age group.
1981年至1985年间，对生活在印度泰米尔纳德邦尼尔吉里斯的1377名部落居民进行了镰状细胞性状研究，这些部落居民包括伊鲁拉人（536人）、帕尼亚人（196人）、库伦巴人（87人）、穆卢克鲁伦巴人（156人）和索利加人（402人）。在阿雷尤尔、科日卡里、科塔吉里和比利吉里兰根山的各个部落诊所就诊的患有各种疾病的患者，如有需要，通过溶解度试验和醋酸纤维素薄膜电泳进行随机筛查。除库伦巴人（19.5%）外，所有研究的部落中HbAS携带者频率为30%至37.8%。尼尔吉里斯西部（内东戈德、卡帕拉及毗邻地区）的携带者频率（37.8%）高于东部（30%）。此外，生活在尼尔吉里斯西部的帕尼亚人和穆卢克鲁伦巴人在10至19岁年龄组中的携带者患病率更高（47%至49%）。在本世纪初，尼尔吉里斯西部疟疾流行猖獗，可能导致许多携带HbAA的儿童死亡，因此在这个特定年龄组中HbAS的频率较高。
