手部脓疱性血管炎
Pustular vasculitis of the hands.
作者信息
Strutton G, Weedon D, Robertson I
机构信息
Department of Pathology, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia.
出版信息
J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):192-8. doi: 10.1016/0190-9622(95)90125-6.
BACKGROUND
Several patients were observed with a peculiar cutaneous eruption limited to the dorsa of the hands and fingers. Clinically the lesions had some resemblance to those seen in Sweet's syndrome, but biopsy specimens showed severe leukocytoclastic vasculitis.
OBJECTIVE
Our purpose was to characterize this eruption clinically and histologically and compare it with previously described diseases.
METHODS
Six patients observed since 1977 are described. Skin biopsy specimens were obtained.
RESULTS
In six women (age, 41 to 79 years) a symmetric eruption of papules and plaques limited to the dorsa of the radial sides of the hands and first three digits developed. The lesions resembled those of Sweet's syndrome and were associated with fever, sterile culture, blood neutrophil leukocytosis, nonresponse to antibiotic therapy, and rapid response to prednisone. Biopsy specimens showed a severe leukocytoclastic vasculitis.
CONCLUSION
These patients appear to have a distinct entity that we have termed pustular vasculitis of the hands.
背景
观察到数例患者出现一种特殊的皮肤疹，局限于手背和手指背侧。临床上，这些损害与斯威特综合征所见的损害有些相似，但活检标本显示为严重的白细胞破碎性血管炎。
目的
我们的目的是从临床和组织学上对这种皮疹进行特征描述，并将其与先前描述的疾病进行比较。
方法
描述了自1977年以来观察到的6例患者。获取了皮肤活检标本。
结果
6名女性（年龄41至79岁）出现了对称分布的丘疹和斑块疹，局限于手桡侧及前三个手指的背侧。这些损害类似于斯威特综合征的损害，并伴有发热、无菌培养、血液中性粒细胞增多、对抗生素治疗无反应以及对泼尼松快速反应。活检标本显示为严重的白细胞破碎性血管炎。
结论
这些患者似乎患有一种独特的疾病，我们将其称为手部脓疱性血管炎。
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