广泛性焦虑障碍、糖尿病与僵人综合征：一些进展与更多问题 - Suppr

GAD, diabetes, and Stiff-Man syndrome: some progress and more questions.

作者信息

Solimena M, Butler M H, De Camilli P

机构信息

Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520-8020.

出版信息

J Endocrinol Invest. 1994 Jul-Aug;17(7):509-20. doi: 10.1007/BF03347745.

DOI:10.1007/BF03347745

PMID:7829825

Abstract

摘要

相似文献

GAD, diabetes, and Stiff-Man syndrome: some progress and more questions.广泛性焦虑障碍、糖尿病与僵人综合征：一些进展与更多问题

J Endocrinol Invest. 1994 Jul-Aug;17(7):509-20. doi: 10.1007/BF03347745.

Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus.僵人综合征和胰岛素依赖型糖尿病中针对谷氨酸脱羧酶（GAD）的自身免疫反应。

Trends Neurosci. 1991 Oct;14(10):452-7. doi: 10.1016/0166-2236(91)90044-u.

Of stiff men and sweet mice: GAD and diabetes.

Lancet. 1991 Dec 7;338(8780):1428-9.

The clinical significance of an autoimmune response against glutamic acid decarboxylase.针对谷氨酸脱羧酶的自身免疫反应的临床意义。

Nat Med. 1996 Feb;2(2):148-53. doi: 10.1038/nm0296-148.

Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.僵人综合征和胰岛素依赖型糖尿病中的谷氨酸脱羧酶自身抗体在表位识别上呈现出异同。

J Immunol. 1996 Jan 15;156(2):818-25.

Anti glutamate-decarboxylase antibodies: a liaison between localisation related epilepsy, stiff-person syndrome and type-1 diabetes mellitus.抗谷氨酸脱羧酶抗体：定位相关癫痫、僵人综合征与1型糖尿病之间的联系。

Ideggyogy Sz. 2014 Jul 30;67(7-8):269-71.

Anti-GAD positive stiff-person syndrome and cerebellar ataxia: two treatable conditions that clinicians should be aware of.抗谷氨酸脱羧酶抗体阳性僵人综合征和小脑共济失调：临床医生应了解的两种可治疗疾病。

Arq Neuropsiquiatr. 2012 Sep;70(9):655-6. doi: 10.1590/s0004-282x2012000900001.

The $64000 question in diabetes continues.

Lancet. 2000 Jul 1;356(9223):4-6. doi: 10.1016/S0140-6736(00)02421-1.

Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer.僵人综合征伴小脑共济失调及高谷氨酸脱羧酶抗体滴度

Intern Med. 2001 Sep;40(9):968-71. doi: 10.2169/internalmedicine.40.968.

[Autoantibodies against GAD and GAD65].

Nihon Rinsho. 1998 Jan;56 Suppl 3:190-5.

引用本文的文献

GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA).谷氨酸脱羧酶65自身抗体及其作为1型糖尿病和成人隐匿性自身免疫性糖尿病（LADA）生物标志物的作用。

Drugs Future. 2011 Nov;36(11):847. doi: 10.1358/dof.2011.036.11.1710754.

Autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes.自身免疫性僵硬人综合征及相关脊髓病：电生理和免疫学过程的理解。

Muscle Nerve. 2012 May;45(5):623-34. doi: 10.1002/mus.23234.

Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.一个患有常染色体隐性痉挛性脑瘫的家族中，谷氨酸脱羧酶67 kDa亚型的错义突变纯合子：与僵人综合征及其他运动障碍的相似之处

BMC Neurol. 2004 Nov 30;4(1):20. doi: 10.1186/1471-2377-4-20.

T-cell reactivity to beta-cell antigens in human insulin-dependent (type 1) diabetes mellitus. Implications for diagnosis and therapy.人类胰岛素依赖型（1型）糖尿病中T细胞对β细胞抗原的反应性。对诊断和治疗的意义。

Clin Rev Allergy Immunol. 2000 Dec;19(3):265-75. doi: 10.1385/CRIAI:19:3:265.

Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.鼠单克隆谷氨酸脱羧酶（GAD）65抗体可识别1型糖尿病和僵人综合征患者体内自身免疫相关的GAD表位区域。

Acta Diabetol. 1996 Sep;33(3):225-31. doi: 10.1007/BF02048548.

本文引用的文献

Glutamic acid decarboxylase in brain.大脑中的谷氨酸脱羧酶

J Biol Chem. 1951 Feb;188(2):789-95.

Progressive fluctuating muscular rigidity and spasm ("stiff-man" syndrome); report of a case and some observations in 13 other cases.进行性波动性肌肉僵硬和痉挛（“僵人”综合征）；1例报告及对其他13例的一些观察

Proc Staff Meet Mayo Clin. 1956 Jul 25;31(15):421-7.

Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse.小鼠谷氨酸脱羧酶62kd形式的分子鉴定

Eur J Neurosci. 1990;2(3):190-202. doi: 10.1111/j.1460-9568.1990.tb00412.x.

A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells.一种由质子泵驱动的γ-氨基丁酸转运体存在于胰腺β细胞的突触样微囊中。

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5317-21. doi: 10.1073/pnas.90.11.5317.

Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.1型糖尿病中谷氨酸脱羧酶主要免疫原性同工型GAD-65的证实及利用真核表达产生的放射性配体测定自身抗体。

J Clin Invest. 1993 May;91(5):2084-90. doi: 10.1172/JCI116431.

Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.

Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3073-7. doi: 10.1073/pnas.90.7.3073.

Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets.人类自身抗体可与人及大鼠胰腺胰岛中的谷氨酸脱羧酶抗原发生反应，但不能与小鼠胰腺胰岛中的该抗原发生反应。

Diabetologia. 1993 Jan;36(1):39-46. doi: 10.1007/BF00399091.

Differential expression of glutamic acid decarboxylase in rat and human islets.大鼠和人胰岛中谷氨酸脱羧酶的差异表达。

Diabetes. 1993 Mar;42(3):484-95. doi: 10.2337/diab.42.3.484.

Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease.谷氨酸脱羧酶抗体可揭示非胰岛素依赖型起病的成人隐匿性自身免疫性糖尿病。

Diabetes. 1993 Feb;42(2):359-62. doi: 10.2337/diab.42.2.359.

Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type.使用重组人胰岛谷氨酸脱羧酶（GAD65）进行的定量测定表明，发病时64K自身抗体阳性可预测糖尿病类型。

J Clin Invest. 1993 Jan;91(1):368-74. doi: 10.1172/JCI116195.

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GAD, diabetes, and Stiff-Man syndrome: some progress and more questions.

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