对谷氨酸脱羧酶的免疫反应与非肥胖糖尿病小鼠的胰岛炎相关。 - Suppr

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超能文献

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

作者信息

Cooke A, Mandel T E

机构信息

Dept. of Pathology, University of Cambridge, England.

出版信息

J Endocrinol Invest. 1994 Jul-Aug;17(7):586-93. doi: 10.1007/BF03347755.

DOI:10.1007/BF03347755

PMID:7829835

Abstract

摘要

相似文献

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.对谷氨酸脱羧酶的免疫反应与非肥胖糖尿病小鼠的胰岛炎相关。

J Endocrinol Invest. 1994 Jul-Aug;17(7):586-93. doi: 10.1007/BF03347755.

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.对谷氨酸脱羧酶的免疫反应与非肥胖糖尿病小鼠的胰岛炎相关。

Nature. 1993 Nov 4;366(6450):72-5. doi: 10.1038/366072a0.

Natural history of humoral immunity to glutamic acid decarboxylase in non-obese diabetic (NOD) mice.非肥胖糖尿病（NOD）小鼠中谷氨酸脱羧酶体液免疫的自然史。

J Autoimmun. 1994 Oct;7(5):643-53. doi: 10.1006/jaut.1994.1049.

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.小鼠胰岛素依赖型糖尿病中T细胞对谷氨酸脱羧酶的自发耐受性丧失。

Nature. 1993 Nov 4;366(6450):69-72. doi: 10.1038/366069a0.

Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice.诱导GAD65特异性调节性T细胞可抑制非肥胖糖尿病小鼠中持续的自身免疫性糖尿病。

Diabetes. 1998 Jun;47(6):894-9. doi: 10.2337/diabetes.47.6.894.

Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice.合成糖脂OCH可预防非肥胖糖尿病（NOD）小鼠的胰岛炎和糖尿病。

J Autoimmun. 2004 Dec;23(4):293-300. doi: 10.1016/j.jaut.2004.09.008.

DNA vaccination encoding glutamic acid decarboxylase can enhance insulitis and diabetes in correlation with a specific Th2/3 CD4 T cell response in non-obese diabetic mice.编码谷氨酸脱羧酶的DNA疫苗可增强非肥胖糖尿病小鼠的胰岛炎和糖尿病，且与特定的Th2/3 CD4 T细胞反应相关。

Clin Exp Immunol. 2004 Aug;137(2):253-62. doi: 10.1111/j.1365-2249.2004.02546.x.

Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse.胰腺白细胞介素-4的表达会导致胰岛反应性Th2细胞的产生，这些细胞可抑制非肥胖糖尿病小鼠中的致糖尿病淋巴细胞。

J Immunol. 1999 Aug 1;163(3):1696-703.

Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells.通过在β细胞中表达或抑制谷氨酸脱羧酶（GAD）来控制非肥胖糖尿病（NOD）小鼠的自身免疫性糖尿病。

Science. 1999 May 14;284(5417):1183-7. doi: 10.1126/science.284.5417.1183.

Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent.谷氨酸脱羧酶65特异性Th2细胞的诱导以及疾病晚期自身免疫性糖尿病的抑制是表位依赖性的。

J Immunol. 1999 Aug 1;163(3):1178-87.

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本文引用的文献

Can islet cell antibodies predict IDDM in the general population?胰岛细胞抗体能否预测普通人群中的胰岛素依赖型糖尿病？

Diabetes Care. 1993 Jan;16(1):45-50. doi: 10.2337/diacare.16.1.45.

Tolerance to IDDM induced by CD4 antibodies in nonobese diabetic mice is reversed by cyclophosphamide.环磷酰胺可逆转非肥胖糖尿病小鼠中由CD4抗体诱导的对胰岛素依赖型糖尿病的耐受性。

Diabetes. 1993 Nov;42(11):1601-5. doi: 10.2337/diab.42.11.1601.

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.抗CD3抗体可诱导非肥胖糖尿病小鼠明显的自身免疫长期缓解。

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):123-7. doi: 10.1073/pnas.91.1.123.

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.对谷氨酸脱羧酶的免疫反应与非肥胖糖尿病小鼠的胰岛炎相关。

Nature. 1993 Nov 4;366(6450):72-5. doi: 10.1038/366072a0.

Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets.非肥胖糖尿病（NOD）小鼠中缺乏针对谷氨酸脱羧酶（GAD）的自身抗体，且该酶在小鼠胰岛中表达水平较低。

Clin Exp Immunol. 1994 Apr;96(1):129-37. doi: 10.1111/j.1365-2249.1994.tb06242.x.

Prevention of diabetes but not insulitis in NOD mice injected with antibody to CD4.给非肥胖糖尿病（NOD）小鼠注射抗CD4抗体可预防糖尿病，但不能预防胰岛炎。

J Autoimmun. 1993 Jun;6(3):301-10. doi: 10.1006/jaut.1993.1026.

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes.胰岛素依赖型糖尿病高危人群中，谷氨酸脱羧酶的体液免疫与细胞免疫之间的负相关关系。

Lancet. 1993 May 29;341(8857):1365-9. doi: 10.1016/0140-6736(93)90940-i.

Active suppression induced by anti-CD4.抗CD4诱导的主动抑制

Eur J Immunol. 1993 Apr;23(4):965-8. doi: 10.1002/eji.1830230431.

Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease.谷氨酸脱羧酶抗体作为胰岛素依赖型糖尿病临床发病前的预测指标。

Lancet. 1994 Jun 4;343(8910):1383-5. doi: 10.1016/s0140-6736(94)92521-6.

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.小鼠胰岛素依赖型糖尿病中T细胞对谷氨酸脱羧酶的自发耐受性丧失。

Nature. 1993 Nov 4;366(6450):69-72. doi: 10.1038/366069a0.

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