Takeda S, Tatara I, Kono K, Arakawa K
Second Department of Internal Medicine, Fukuoka University School of Medicine.
Kansenshogaku Zasshi. 1994 Nov;68(11):1417-20. doi: 10.11150/kansenshogakuzasshi1970.68.1417.
An 18-year-old female was given prednisolone and azathioprine for treatment of systemic lups erythematosus. She was admitted to Fukuoka University Hospital because of headache and vomiting. Examinations revealed she was suffering from cryptococcal meningitis. Fluconazole (FLCZ) 400 mg a day was administrated for therapy. Her general condition improved and the serum level of cryptococcal antigen decreased one month after therapy. This therapy resulted in abatement of subjected symptoms and sterilization of the cerebral spinal fluid. This case suggested that therapy with FLCZ alone is useful for patients with cryptococcal meningitis, therefore the standard therapy with amphotericin B (AMPH) or the combination.
一名18岁女性因系统性红斑狼疮接受泼尼松龙和硫唑嘌呤治疗。她因头痛和呕吐入住福冈大学医院。检查发现她患有新型隐球菌性脑膜炎。给予氟康唑（FLCZ）每日400毫克进行治疗。治疗1个月后，她的一般状况有所改善，血清新型隐球菌抗原水平下降。该治疗使相关症状减轻，脑脊液除菌。该病例表明，单独使用氟康唑治疗对新型隐球菌性脑膜炎患者有效，因此无需使用两性霉素B（AMPH）的标准治疗或联合治疗。
