Kinsella A R, Bowie G L, Field J K, Jones A S
Department of Surgery, University of Liverpool.
J Laryngol Otol. 1994 Nov;108(11):957-61. doi: 10.1017/s0022215100128622.
A reduction in cell adhesiveness and cell invasion are essential steps in tumour progression. In the present study six tongue carcinoma cell lines were compared with regard to their invasive potential in two in vitro invasion assay systems and for their patterns of expression of the cell-cell adhesion molecule E-cadherin. The three cell lines negative for E-cadherin expression were invasive in both assays. One cell line with strong E-cadherin expression was strongly invasive and one weakly invasive. One cell line with reduced E-cadherin expression was weakly invasive. There was no significant pattern to these findings (chi 2 = 0.375; p = 0.54). This supports previous studies from this group that suggest that E-cadherin is only one of the presumably many molecules involved in tumour progression in squamous cell carcinoma of the tongue.
细胞黏附性降低和细胞侵袭是肿瘤进展的关键步骤。在本研究中，比较了六种舌癌细胞系在两种体外侵袭检测系统中的侵袭潜能以及它们的细胞间黏附分子E-钙黏蛋白的表达模式。E-钙黏蛋白表达阴性的三个细胞系在两种检测中均具有侵袭性。一个E-钙黏蛋白表达强的细胞系侵袭性强，一个弱侵袭性。一个E-钙黏蛋白表达降低的细胞系弱侵袭性。这些结果没有显著规律（χ2 = 0.375；p = 0.54）。这支持了该研究小组之前的研究，即E-钙黏蛋白只是舌鳞状细胞癌肿瘤进展中可能涉及的众多分子之一。
