犬心肌中放射性药物分布的单光子发射计算机断层扫描（SPECT）定量评估。

Evaluation of SPECT quantification of radiopharmaceutical distribution in canine myocardium.

作者信息

Li J, Jaszczak R J, Greer K L, Gilland D R, DeLong D M, Coleman R E

机构信息

Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.

出版信息

J Nucl Med. 1995 Feb;36(2):278-86.

PMID:7830132

Abstract

UNLABELLED

This study evaluates the quantitative accuracy of SPECT for in vivo distributions of 99mTc radiopharmaceuticals using fanbeam (FB) and parallel-beam (PB) collimators and compares uniform and nonuniform attenuation correction methods in terms of quantitative accuracy.

METHODS

SPECT quantification of canine myocardial radioactivity was performed followed by well counter measurements of extracted myocardial tissue samples. Transmission scans using a line source and an FB collimator were performed to generate nonuniform attenuation maps of the canine thorax. Emission scans with two energy windows were acquired. Images were reconstructed using a filtered backprojection algorithm, with a dual-window scatter subtraction combined with either no attenuation compensation or single iteration Chang attenuation compensation based on an uniform attenuation map (mu = 0.152 cm-1) or the nonuniform transmission map.

RESULTS

The measured mean counts from the SPECT images were converted to radionuclide concentrations (MBq/g) using a standard source calibration and were compared with those obtained using the well counter.

CONCLUSION

The experimental results demonstrate that, compared with well counter values, the in vivo distributions of 99mTc were most accurately determined in FB and PB SPECT reconstructions with nonuniform attenuation compensation, under-estimated without attenuation compensation and overestimated with uniform attenuation compensation.

摘要

未标记

本研究评估了使用扇形束（FB）和平行束（PB）准直器的单光子发射计算机断层扫描（SPECT）对99mTc放射性药物体内分布的定量准确性，并在定量准确性方面比较了均匀和非均匀衰减校正方法。

方法

对犬心肌放射性进行SPECT定量，随后对提取的心肌组织样本进行井型计数器测量。使用线源和FB准直器进行透射扫描，以生成犬胸部的非均匀衰减图。采集具有两个能量窗的发射扫描图像。使用滤波反投影算法重建图像，采用双窗散射减法，结合基于均匀衰减图（μ = 0.152 cm-1）或非均匀透射图的无衰减补偿或单次迭代张衰减补偿。