Asano K, Yamano M, Haruyama K, Ikawa E, Nakano K, Kurono M, Wada O
Department of Pharmacology, Mie Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd., Japan.
J Toxicol Sci. 1994 Oct;19 Suppl 2:131-43. doi: 10.2131/jts.19.supplementii_131.
A histopathological study was performed to examine the influence of propagermanium and germanium dioxide (GeO2) on chemically induced renal lesions in rats. Animals were treated with adriamycin or mercuric chloride to induce glomerular or proximal tubular damage, and then given drinking water containing propagermanium (480 or 2,400 ppm solution) or GeO2 (300 or 1,500 ppm solution: equivalent to propagermanium in terms of germanium contents). The distal tubular epithelium after 8 weeks dosage with the 1,500 ppm solution of GeO2 was characterized by vacuolization and deposits of PAS-positive material not only in adriamycin-treated rats, but also in normal rats. In contrast, propagermanium administration was not associated with any alternation in the changes induced by adriamycin or mercuric chloride. We previously clarified that propagermanium had no biochemical influence on the renal function of these renal injured rats. The histological demonstration that this compound does not exert renal toxicity, even when given at a high dosage to renal injured rats, further indicates that it would not exacerbate renal dysfunction already present. This confirms that propagermanium may be a safe compound for use in individuals with compromised kidneys.
进行了一项组织病理学研究，以检验丙锗和二氧化锗（GeO2）对化学诱导的大鼠肾损伤的影响。用阿霉素或氯化汞处理动物以诱导肾小球或近端肾小管损伤，然后给它们饮用含丙锗（480或2400 ppm溶液）或GeO2（300或1500 ppm溶液：就锗含量而言等同于丙锗）的水。在用1500 ppm GeO2溶液给药8周后，远曲小管上皮出现空泡化，并且不仅在阿霉素处理的大鼠中，而且在正常大鼠中都有PAS阳性物质沉积。相比之下，给予丙锗与阿霉素或氯化汞诱导的变化无任何改变相关。我们之前已阐明丙锗对这些肾损伤大鼠的肾功能无生化影响。组织学证明该化合物即使以高剂量给予肾损伤大鼠也不产生肾毒性，进一步表明它不会加重已存在的肾功能障碍。这证实丙锗对于肾受损个体可能是一种安全的化合物。
