Kawanami T, Kato T, Llena J F, Hirano A, Sasaki H
Department of Pathology, Montefiore Medical Center, New York.
Neurosci Lett. 1994 Aug 1;176(2):178-80. doi: 10.1016/0304-3940(94)90076-0.
We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.
我们用抗突触素（SYP）抗体对4例橄榄体肥大病例和6例对照病例的下橄榄核进行了免疫组织化学检查。我们的研究揭示了肥大橄榄体中SYP免疫反应模式的改变，尽管神经纤维网中的免疫反应性降低，但神经元细胞体上SYP免疫反应点的数量增加。由于SYP是突触前囊泡的标记蛋白，下橄榄核中的突触前终末在橄榄体肥大过程中似乎会改变其分布。
