丙戊茶碱增强豚鼠海马切片中长时程增强的形成。

Propentofylline enhances the formation of long-term potentiation in guinea pig hippocampal slices.

作者信息

Yamada Y, Nakamura H, Okada Y

机构信息

Department of Physiology, School of Medicine, Kobe University, Japan.

出版信息

Neurosci Lett. 1994 Aug 1;176(2):189-92. doi: 10.1016/0304-3940(94)90079-5.

DOI:10.1016/0304-3940(94)90079-5

PMID:7830944

Abstract

The postsynaptic field potential (population spike; PS) was recorded in the CA1 area of guinea pig hippocampal slices in response to electrical stimulation of Schaffer's collateral. After tetanic stimulation (100 Hz for 1 s) to Schaffer's collateral, the PS amplitude increased to 127.9 +/- 7.7% (mean +/- S.E.M.) of the original level at 20 min and 140.1 +/- 7.7% at 60 min, and formed long-term potentiation (LTP). After application of 10 nM propentofylline, a synthetic xanthine derivative, which did not enhance the amplitude of the PS evoked by the test stimulus, the tetanic stimulation increased the amplitude to 160.3 +/- 3.8% at 20 min and 173.3 +/- 4.3% at 60 min. Thus, propentofylline enhances the formation of LTP in hippocampal slices.

摘要

在豚鼠海马切片的CA1区记录突触后场电位（群体锋电位；PS），以响应施affer侧支的电刺激。对施affer侧支进行强直刺激（100 Hz，持续1 s）后，PS幅度在20分钟时增加到原始水平的127.9±7.7%（平均值±标准误），在60分钟时增加到140.1±7.7%，并形成长时程增强（LTP）。应用10 nM丙戊茶碱（一种合成黄嘌呤衍生物，它不会增强测试刺激诱发的PS幅度）后，强直刺激使幅度在20分钟时增加到160.3±3.8%，在60分钟时增加到173.3±4.3%。因此，丙戊茶碱增强了海马切片中LTP的形成。