Tanida S, Hasegawa T, Yamano T, Yoneda M
J Antibiot (Tokyo). 1976 Jul;29(7):754-8. doi: 10.7164/antibiotics.29.754.
Desdanine inhibited the plaque formation of male-specific coliphages but not that of other coliphages tested. Desdanine also suppressed the multiplication of both RNA phage Q beta and filamentous DNA phage f1 at the concentration of 3.13 approximately 6.25 mug/ml which had no influence on the growth of their host cells. However, the inhibitory effect on the phage multiplication was not due to the inactivation of phage particles nor the prevention of phage adsorption and penetration into the host cells. Desdanine also inhibited the transfer of R plasmid, R 100-1, in E. coli at 6.25 approximately 12.5 mug/ml without affecting the viability of donor and recipient cells.
去甲山梗菜碱抑制雄性特异性大肠杆菌噬菌体的噬菌斑形成，但不抑制所测试的其他大肠杆菌噬菌体的噬菌斑形成。去甲山梗菜碱在浓度为3.13至6.25微克/毫升时，还能抑制RNA噬菌体Qβ和丝状DNA噬菌体f1的增殖，而此浓度对它们宿主细胞的生长没有影响。然而，对噬菌体增殖的抑制作用并非由于噬菌体颗粒的失活，也不是由于阻止噬菌体吸附和侵入宿主细胞。去甲山梗菜碱在浓度为6.25至12.5微克/毫升时，还能抑制大肠杆菌中R质粒R 100-1的转移，而不影响供体细胞和受体细胞的活力。
