Prophylactic use of monophosphoryl lipid A in patients at risk for sepsis.
作者信息
Rudbach J A, Myers K R, Rechtman D J, Ulrich J T
机构信息
Ribi ImmunoChem Research, Inc., Hamilton, Montana 59840.
出版信息
Prog Clin Biol Res. 1994;388:107-24.
PMID:7831353
Abstract
摘要
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Prophylactic use of monophosphoryl lipid A in patients at risk for sepsis.对有败血症风险的患者预防性使用单磷酰脂质A。
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Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration.盲肠结扎穿孔术后肺和肝脏的基因表达：单磷酰脂质A预防可减轻脓毒症诱导的细胞因子、趋化因子表达及中性粒细胞浸润。
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Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages.脂多糖和单磷酰脂质A对小鼠巨噬细胞中白细胞介素-12、γ干扰素和白细胞介素-10 mRNA的产生有不同的调节作用。
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Monophosphoryl lipid A behaves as a T-cell-independent type 1 carrier for hapten-specific antibody responses in mice.单磷酰脂质A在小鼠中作为半抗原特异性抗体反应的1型非T细胞依赖性载体发挥作用。
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