急性和慢性乙醇给药对神经降压素系统的影响。
Effects of acute and chronic ethanol administration on neurotensinergic systems.
作者信息
Erwin V G, Jones B C, Myers R
机构信息
Alcohol Research Center, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262.
出版信息
Ann N Y Acad Sci. 1994 Oct 31;739:185-96. doi: 10.1111/j.1749-6632.1994.tb19820.x.
A summary of pharmacogenetic studies designed to test the hypothesis that NT receptors might mediate or regulate some of the actions of ethanol is presented. Indeed, there are significant genetic correlations between ethanol-induced locomotor activation and high-affinity NT receptor densities in the FC. The results suggest that further studies are needed to determine the role of NT receptors in the FC and MPFC in regulating locomotor activity. In other studies, chronic ethanol treatment, under conditions that produced tolerance to ethanol and caused NT receptor downregulation in the NA and VMB, caused tolerance to locomotor inhibitory effects of centrally administered NT and blunted the effects of intra-VTA NT on dopamine metabolism in the NA and CP. The results show a relationship between NT receptor densities and pharmacological effects of ethanol.
本文介绍了旨在检验神经降压素（NT）受体可能介导或调节乙醇某些作用这一假说的药物遗传学研究总结。实际上，乙醇诱导的运动激活与前额叶皮质（FC）中高亲和力NT受体密度之间存在显著的遗传相关性。结果表明，需要进一步研究以确定NT受体在FC和内侧前额叶皮质（MPFC）中调节运动活动的作用。在其他研究中，在产生乙醇耐受性并导致伏隔核（NA）和腹侧被盖区（VMB）中NT受体下调的条件下进行慢性乙醇处理，会导致对中枢给予NT的运动抑制作用产生耐受性，并减弱腹侧被盖区（VTA）内NT对NA和尾状核（CP）中多巴胺代谢的影响。结果显示了NT受体密度与乙醇药理作用之间的关系。
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