Monhart V, Fusek J, Brndiar M, Tlustakova M
Third Department of Internal Medicine, Central Army Hospital, Prague, Czech Republic.
Artif Organs. 1994 Oct;18(10):770-2. doi: 10.1111/j.1525-1594.1994.tb03317.x.
The aim of this study was to evaluate the efficiency of hemoperfusion (HP) through coated resin adsorbent Synachrom E-5 in animal intoxications with organophosphate inhibitors of cholinesterases type of nerve agents. Five anesthetized dogs were intoxicated with 2 to 6 LD50 of VX substance and another 4 with 2 to 3 LD50 sarine. Both nerve agents were given i.m. after starting 5 h HP. The clinical and laboratory tests were monitored during each HP. HP therapy prevented the development of serious signs of intoxication provided that the administered quantity of both sarine and the VX substance was only 2 doses of LD50. Specific antidote therapy was necessary to prevent cardiorespiratory failure in animals intoxicated with a higher dose of poison. The results obtained show that HP through Synachrom E-5 in intoxication with nerve agents sarine and the VX type is only partially successful.
本研究的目的是评估通过涂覆树脂吸附剂Synachrom E-5进行血液灌流（HP）对动物因神经毒剂类型的有机磷酸酯胆碱酯酶抑制剂中毒的疗效。五只麻醉犬用2至6倍半数致死剂量（LD50）的VX物质中毒，另外四只用2至3倍LD50的沙林中毒。两种神经毒剂均在开始血液灌流5小时后肌肉注射。在每次血液灌流期间监测临床和实验室检查。只要给予的沙林和VX物质的量仅为2倍LD50剂量，血液灌流治疗就能防止严重中毒症状的出现。对于中毒剂量较高的动物，需要进行特异性解毒剂治疗以预防心肺衰竭。所获得的结果表明，通过Synachrom E-5进行血液灌流对沙林和VX型神经毒剂中毒仅部分成功。
