Wang C, Glisson J R
Department of Avian Medicine, University of Georgia, Athens 30602-4875.
Avian Dis. 1994 Jul-Sep;38(3):506-14.
Chicken antisera produced against the detergent-insoluble fraction of in vivo-grown P-1059 (serotype 3) Pasteurella multocida passively protected against heterologous X-73 (serotype 1) challenge. Likewise, antisera from chickens that survived infection by live P-1059 provided passive heterologous protection. The two antisera, which contained cross-protection antibodies, were adsorbed with the detergent-insoluble fraction of in vitro-grown P-1059 and still passively cross-protected against heterologous serotype challenge. The proteins of in vivo-grown P-1059 that had molecular weights of 204,000, 192,000, 179,000, and 153,000, which were recognized by the adsorbed antisera on immunoblots, may be responsible for cross-protection.
用体内培养的多杀性巴氏杆菌P-1059（血清型3）的去污剂不溶性组分制备的鸡抗血清，对异源X-73（血清型1）攻击具有被动保护作用。同样，感染活P-1059后存活的鸡的抗血清也提供了被动异源保护。这两种含有交叉保护抗体的抗血清，用体外培养的P-1059的去污剂不溶性组分进行吸附，仍然对异源血清型攻击具有被动交叉保护作用。在免疫印迹上被吸附抗血清识别的、体内培养的P-1059中分子量为204,000、192,000、179,000和153,000的蛋白质，可能是交叉保护的原因。
