Bai Y, Cook M E
Department of Nutritional Sciences, University of Wisconsin, Madison 53706.
Avian Dis. 1994 Jul-Sep;38(3):557-62.
Tibial dyschondroplasia (TD)-like lesions were induced in New Hampshire x Single-Comb White Leghorn cross chicks (NH x SCWL) by feeding excess levels of cysteine. The chicks fed a corn/soybean-meal-based diet had no spontaneous TD. The chicks fed the basal diet supplemented with 1.5% or 3.0% cysteine showed more than 50% TD-like lesions at 10 days of age; in another experiment, 1.6% cysteine induced TD (15%) at 3 weeks of age. A low incidence of rachitic-like lesions was found in Expt. 2 but was not associated with the dietary treatments. The TD-like lesion had a normal upper growth plate and a large mass of cartilage extending into the metaphysis; in contrast, the rachitic-like lesion had a widened upper growth plate. Microscopic examinations of the growth plates showed a widened prehypertrophic zone for the TD-like lesion and a widened proliferative zone for the rachitic-like lesion compared with the normal growth plate.
通过饲喂过量的半胱氨酸，在新罕布什尔鸡与单冠白来航鸡杂交雏鸡（NH×SCWL）中诱发了类似胫骨软骨发育不良（TD）的病变。喂食基于玉米/豆粕的日粮的雏鸡没有自发性TD。喂食添加了1.5%或3.0%半胱氨酸的基础日粮的雏鸡在10日龄时出现了超过50%的类似TD的病变；在另一项实验中，1.6%的半胱氨酸在3周龄时诱发了TD（15%）。在实验2中发现了低发生率的类似佝偻病的病变，但与日粮处理无关。类似TD的病变有一个正常的生长板上部，并有大量软骨延伸至干骺端；相比之下，类似佝偻病的病变有一个增宽的生长板上部。与正常生长板相比，生长板的显微镜检查显示，类似TD的病变的增殖前区增宽，类似佝偻病的病变的增殖区增宽。
