Proudman T W, Moore M H, Abbott A H, David D J
Australian Craniofacial Unit, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
J Craniofac Surg. 1994 Sep;5(4):218-22. doi: 10.1097/00001665-199409000-00004.
Although most interest centers on the craniofacial region in Crouzon's disease, noncraniofacial manifestations are important because they may complicate both diagnosis and management. A population of 59 patients with Crouzon's disease was reviewed to determine the frequency of these deformities. Stylohyoid ligament calcification (50%) and cervical spine (40%) and elbow (18%) abnormalities were the most common. Minor hand deformities (10%), other musculoskeletal deformities (7%), and visceral anomalies (7%) were also seen. Acanthosis nigricans was not present in this population. Recommendations are made for the assessment and management of Crouzon's disease with reference to these areas.
