Berger C, Durand C, Françoise M, Gouyon J B
Service de pédiatrie 2, Hôpital d'Enfants, Dijon, France.
Arch Pediatr. 1994 Nov;1(11):998-1003.
Incidence of aortic thromboses in the neonatal period is significantly increased after umbilicar artery catheterization.
Fourty neonates (GA: 34.7 +/- 7.2 wks and birth weight: 2377 +/- 786 g) were prospectively studied in order to assess frequency and natural history of aortic thromboses due to umbilical artery catheterization. Investigation was based on serial real-time ultrasonography (2.3 times/week). Presence of aortic thrombus was correlated with the existence of clinical complications and the results of biological findings (prothrombin and fibrinogen levels; hematocrit) and platelet number.
Aortic thrombosis was found in six patients (15%); it was clinically asymptomatic in two (5%). A vascular wall-fixed catheter was shown in ten infants (25%); this finding was associated with thrombosis in five cases and preceded thrombosis in one other. The presence of thrombus and/or abnormal position of the catheter was not correlated with gestational age, birth weight, duration of catheterization, blood hemostasis and results of bacteriological cultures of the tip of the catheter.
Ultrasonographic control must be repeated after umbilical artery catheterization. It permits evaluation of renal flux and can lead to removal of catheter and/or peculiar therapeutic measures.
脐动脉插管后新生儿期主动脉血栓形成的发生率显著增加。
前瞻性研究了40例新生儿(胎龄:34.7±7.2周,出生体重:2377±786克),以评估脐动脉插管所致主动脉血栓形成的发生率及自然病程。研究基于系列实时超声检查(每周2.3次)。主动脉血栓的存在与临床并发症的发生、生物学检查结果(凝血酶原和纤维蛋白原水平、血细胞比容)及血小板数量相关。
6例患者(15%)发现主动脉血栓形成;其中2例(5%)临床无症状。10例婴儿(25%)显示有血管壁固定导管;这一发现与5例血栓形成相关,且在另1例血栓形成之前出现。血栓的存在和/或导管位置异常与胎龄、出生体重、插管持续时间、止血情况及导管尖端细菌培养结果无关。
脐动脉插管后必须重复进行超声检查监测。它有助于评估肾血流量,并可导致导管拔除和/或采取特殊治疗措施。