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[极端热暴露期间适应性补偿反应形成的特异性和非特异性机制]

[The specific and nonspecific mechanisms of the formation of adaptive-compensatory reactions during extreme exposure to heat].

作者信息

Shleĭfman F M, Stezhka V A, Onikienko F A, Baranova N P, Nazarenko V I

出版信息

Med Tr Prom Ekol. 1994(9):7-10.

PMID:7834236
Abstract

A total of 250 white male rats were subjected to 48 hours experiment in order to study specific (functional state of thermoregulation, heart muscle, brain cortex) and nonspecific (ration of free radical oxidation activity to antioxidant system activity) mechanisms of adaptational and compensatory reactions, those of alteration and restoration after single critical heating (temperature 41.5 +/- 0.5 degrees C) during 1 hour. The animals appeared to develop no adaptation to the studied heating level, that was demonstrated by assessment of specific regulatory systems and by studies of free radical oxidation and antioxidant system activities.

摘要

为了研究适应和代偿反应的特定(体温调节、心肌、大脑皮层的功能状态)和非特定(自由基氧化活性与抗氧化系统活性的比率)机制,以及单次临界加热(温度41.5±0.5摄氏度,持续1小时)后改变和恢复的机制,总共250只雄性白鼠接受了48小时的实验。通过对特定调节系统的评估以及对自由基氧化和抗氧化系统活性的研究表明,这些动物似乎未对所研究的加热水平产生适应。

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