[The specific and nonspecific mechanisms of the formation of adaptive-compensatory reactions during extreme exposure to heat].

A total of 250 white male rats were subjected to 48 hours experiment in order to study specific (functional state of thermoregulation, heart muscle, brain cortex) and nonspecific (ration of free radical oxidation activity to antioxidant system activity) mechanisms of adaptational and compensatory reactions, those of alteration and restoration after single critical heating (temperature 41.5 +/- 0.5 degrees C) during 1 hour. The animals appeared to develop no adaptation to the studied heating level, that was demonstrated by assessment of specific regulatory systems and by studies of free radical oxidation and antioxidant system activities.