Smetters D K, Hahm J, Sur M
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Brain Res. 1994 Sep 26;658(1-2):168-78. doi: 10.1016/s0006-8993(09)90023-3.
Recent studies have shown that electrical activity, particularly that mediated by NMDA receptors, has a profound effect on the development of specific neuronal connections. Blocking NMDA receptors in the ferret's lateral geniculate nucleus prevents the segregation of retinal afferents into ON and OFF sublaminae. We have now examined the involvement of NMDA receptors in the separation of afferents from the two eyes that occurs in the lateral geniculate nucleus several weeks earlier in development. Blockade of NMDA receptor activity does not appear to interfere with this eye-specific segregation.
最近的研究表明，电活动，尤其是由NMDA受体介导的电活动，对特定神经元连接的发育有深远影响。阻断雪貂外侧膝状核中的NMDA受体会阻止视网膜传入纤维分离成ON和OFF亚层。我们现在已经研究了NMDA受体在发育早期几周时外侧膝状核中发生的来自两只眼睛的传入纤维分离过程中的作用。阻断NMDA受体活性似乎并不干扰这种眼特异性分离。
