[脊髓灰质炎抗体母婴转移的纵向研究]

[A longitudinal study on maternal-fetal transfer of antibody against poliomyelitis].

作者信息

You E, Yang Q, Yang Q L

机构信息

Disease Prevention Center, Dong-feng Motor Corporation, Shi Yan.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1994 Jun;15(3):158-61.

PMID:7834692

Abstract

A study on antibody distribution and titer against poliovirus in 67 mothers and their 60-day-old new-born babies was carried out in Shi-yan, Hubei Province. The positive rates and the geometric mean titers of antibodies against Types I-II poliovirus in mothers were 98.58%, 1:32.67; 95.5%, 1:30.07; 92.5%, 1:14.58, respectively. In their 60-day-old babies, the antibody positive rates and geometric mean titers fell obviously: they were 34.3%, 1:2.45; 34.3%, 1:2.22; and 14.9%, 1:1.34, respectively. The authors suggest to immune those neonates (OPV zero), or to immune those mothers beginning from 28 weeks of pregnancy in order to raise the antibody titer and protect their babies during the early days.

摘要

在湖北省十堰市对67名母亲及其60日龄新生儿进行了一项关于抗脊髓灰质炎病毒抗体分布和滴度的研究。母亲中抗I - II型脊髓灰质炎病毒抗体的阳性率和几何平均滴度分别为98.58%，1:32.67；95.5%，1:30.07；92.5%，1:14.58。在其60日龄婴儿中，抗体阳性率和几何平均滴度明显下降：分别为34.3%，1:2.45；34.3%，1:2.22；14.9%，1:1.34。作者建议对这些新生儿（OPV零剂次）进行免疫，或从妊娠28周开始对母亲进行免疫，以提高抗体滴度并在早期保护其婴儿。