医院工作人员乙肝病毒标志物检测及乙肝疫苗接种效果观察

[Investigation on HBV-M among hospital workers and observation on the efficacy of vaccination against type B hepatitis].

作者信息

Wu Z, Gan C, Wang A

机构信息

Peking Union Hospital.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1994 Jun;15(3):165-6.

PMID:7834694

Abstract

An epidemiological study on HBV infection among 315 staff of PUMC Hospital was carried out with detection of HBsAg, anti-HBs and anti-HBc by ELISA. The results showed that 138 persons had one or more markers of HBV infection and an overall HBV prevalence rate 43.8%. The positive rates of HBsAg anti-HBs, anti-HBc were 6.3%, 28.9% and 8.6%, respectively. This indicates that HBV infection is a risk factor for medical staff, but there was no significant difference among medical, surgical and other members. In 1992, 177 workers whose HBV markers were negative received 3 doses of HB vaccine at 0, 1 and 6 months, respectively. 91.3 percent of them showed an anti-HBs response one month after the last inoculation. The result shows that our national made HB vaccine is safe and immunogenic.

摘要

对北京协和医院315名工作人员进行了乙肝病毒（HBV）感染的流行病学研究，采用酶联免疫吸附测定法（ELISA）检测乙肝表面抗原（HBsAg）、乙肝表面抗体（抗-HBs）和乙肝核心抗体（抗-HBc）。结果显示，138人有一项或多项HBV感染标志物，总体HBV感染率为43.8%。HBsAg、抗-HBs、抗-HBc的阳性率分别为6.3%、28.9%和8.6%。这表明HBV感染是医务人员面临的一个风险因素，但在医疗、外科及其他人员之间无显著差异。1992年，177名HBV标志物阴性的工作人员分别于0、1和6个月接种3剂乙肝疫苗。末次接种1个月后，91.3%的人出现抗-HBs反应。结果表明，我国生产的乙肝疫苗安全且具有免疫原性。