Hodgkin J
MRC Laboratory of Molecular Biology, Cambridge, England.
Dev Genet. 1994;15(6):471-7. doi: 10.1002/dvg.1020150605.
The nematode Caenorhabditis elegans has been the subject of many detailed investigations in developmental biology. Molecular analyses have failed to detect covalent alterations to DNA, such as methylation or rearrangement, during development of C. elegans. Genetic experiments indicate that imprinting of gamete genomes does not occur to any significant extent. The maintenance of gene activity states in this organism may depend predominantly on regulatory gene circuitry. Some possible examples of maintenance circuits are discussed.
线虫秀丽隐杆线虫一直是发育生物学中许多详细研究的对象。分子分析未能检测到秀丽隐杆线虫发育过程中DNA的共价改变，如甲基化或重排。遗传实验表明，配子基因组的印记在很大程度上并不发生。该生物体中基因活性状态的维持可能主要依赖于调控基因回路。文中讨论了一些维持回路的可能例子。
