Kato E, Takahashi S, Abe T, Kawamorita A, Tohgi H
Department of Neurology, Iwate Medical University.
Rinsho Shinkeigaku. 1994 Oct;34(10):1013-7.
A 63-year-old man was admitted to the hospital with a 1,5-year history of progressive dementia, supranuclear ophthalmoplegia, pseudobulbar palsy, rigidity and dystonia in the neck and the upper trunk. Magnetic resonance imagings showed severe atrophy of the frontal lobe and the brainstem. He was diagnosed as having progressive supranuclear palsy (PSP). Rigidity, nuchal dystonia, frequent micturition, and profuse sweating ameliorated after trazodone administration. Furthermore, additional administration of L-dopa and droxidopa improved his pseudobulbar palsy, akinesia, and lack of initiative. Single photon emission tomography using IMP after medication showed increased IMP-uptake in the frontal areas and the basal ganglia compared with that before medication. This patient illustrates a substantial role of impairments in the serotonin system in the production of some PSP symptoms.
一名63岁男性因进行性痴呆、核上性眼肌麻痹、假性球麻痹、颈部和上躯干僵硬及肌张力障碍1.5年的病史入院。磁共振成像显示额叶和脑干严重萎缩。他被诊断为进行性核上性麻痹（PSP）。曲唑酮给药后，僵硬、颈部肌张力障碍、尿频和多汗症状有所改善。此外，额外给予左旋多巴和屈昔多巴改善了他的假性球麻痹、运动不能和缺乏主动性。用药后使用IMP进行的单光子发射断层扫描显示，与用药前相比，额叶区域和基底神经节的IMP摄取增加。该患者表明血清素系统功能障碍在某些PSP症状产生中起重要作用。
