Chen Y Q, Dai K R, Qiu S J, Zhu Z A
Department of Orthopaedics, Ninth People's Hospital Shanghai Second Medical University.
Chin Med J (Engl). 1994 Oct;107(10):766-70.
Forty adult New Zealand rabbits were used in this experiment. Four rabbits served as control and the rest 36 being divided into 3 groups, each of which was fixed respectively with methylmethacrylate, titanium alloy and stainless steel plate on the left intact tibiae. The cortical bone beneath the plate was harvested at 2, 4, 8 and 12 weeks after operation and observed by means of using transmission electron microscope. The major ultrastructural changes after internal fixation with different stiffness plates were alteration of osteocyte life cycle, perilacunar matrix and disorder of osteoblast and osteoblast coupling. The greater the stiffness of the plate, the greater the ultrastructural change.
本实验使用了40只成年新西兰兔。4只兔子作为对照，其余36只分为3组，每组分别在左侧完整胫骨上用甲基丙烯酸甲酯、钛合金和不锈钢板进行固定。术后2、4、8和12周采集钢板下方的皮质骨，并用透射电子显微镜进行观察。不同刚度钢板内固定后的主要超微结构变化为骨细胞生命周期、骨陷窝周围基质改变以及成骨细胞与破骨细胞耦联紊乱。钢板刚度越大，超微结构变化越大。
