Goadsby P J
Department of Neurology, Prince Henry Hospital, Sydney, NSW, Australia.
Eur Neurol. 1994;34 Suppl 2:35-9. doi: 10.1159/000119530.
Cluster headache is a rare form of severe idiopathic headache characterized by unilateral short-lasting episodes of excruciating pain in association with autonomic disturbances. Subcutaneous sumatriptan has been investigated as an acute treatment for cluster headache in two randomized, double-blind, placebo-controlled, crossover trials. About 75% of patients given subcutaneous sumatriptan 6 mg reported headache relief within 15 min, in comparison with 26-35% given placebo (p < 0.001 in both studies). The need for rescue medication (100% oxygen by inhalation) at 15 min was significantly lower after sumatriptan treatment as were the severity of functional disability and incidence of non-headache symptoms. Results of a long-term study indicate that the tolerability and efficacy of sumatriptan 6 mg is maintained in long-term use, and that there is no evidence of tachyphylaxis.
丛集性头痛是一种罕见的严重特发性头痛，其特征为单侧短暂发作的剧痛，并伴有自主神经功能紊乱。在两项随机、双盲、安慰剂对照的交叉试验中，已对皮下注射舒马曲坦作为丛集性头痛的急性治疗方法进行了研究。给予皮下注射6毫克舒马曲坦的患者中，约75%报告在15分钟内头痛缓解，相比之下，给予安慰剂的患者为26%-35%（两项研究中p均<0.001）。舒马曲坦治疗后15分钟时对急救药物（吸入100%氧气）的需求显著降低，功能残疾的严重程度和非头痛症状的发生率也是如此。一项长期研究结果表明，长期使用6毫克舒马曲坦时，其耐受性和疗效得以维持，且没有快速耐受的证据。
