胃张力决定胃对扩张的敏感性。

Gastric tone determines the sensitivity of the stomach to distention.

作者信息

Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada J R

机构信息

Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Spain.

出版信息

Gastroenterology. 1995 Feb;108(2):330-6. doi: 10.1016/0016-5085(95)90057-8.

DOI:10.1016/0016-5085(95)90057-8

PMID:7835573

Abstract

BACKGROUND/AIMS: Whether meal-related symptoms such as postcibal epigastric fullness and discomfort are caused by hypotonic gastric expansion or gastric hypertension is unknown. This study investigated whether symptoms in healthy individuals in response to gastric distention are produced by gastric expansion or by an increase in intragastric pressure.

METHODS

Increasing gastric distentions (for 5 minutes at 5-minute intervals) at fixed pressure levels (in 2-mm Hg increments) and at fixed volume levels (in 200-mL increments) were performed in 10 healthy subjects per group; perception was measured on a 0-6 scale. Distentions were performed during intravenous infusion of saline (basal) and during gastric relaxation by intravenous administration of glucagon (4.8-micrograms/kg bolus plus 9.6 micrograms.kg-1.h-1 infusion).

RESULTS

The same distending pressure tested produced 30% +/- 9% larger intragastric volumes and 80% +/- 44% higher perception scores when the stomach was relaxed by glucagon (P < 0.05 vs. basal for both). In contrast, the same distending volumes tested produced 25% +/- 7% lower intragastric pressures and 21% +/- 12% lower perception scores when the stomach was relaxed (P < 0.05 vs. basal for both).

CONCLUSIONS

Epigastric symptoms in response to gastric distention are influenced by both the intragastric pressure and the intragastric volume.

摘要

背景/目的：餐后上腹部饱胀和不适等与进餐相关的症状是由胃低张性扩张还是胃内高压引起尚不清楚。本研究调查了健康个体对胃扩张的反应症状是由胃扩张还是胃内压升高所致。

方法

每组10名健康受试者，分别在固定压力水平（以2毫米汞柱递增）和固定容积水平（以200毫升递增）下，以5分钟的间隔进行5分钟的递增胃扩张；采用0至6级评分法测量感觉。在静脉输注生理盐水（基础状态）期间以及静脉注射胰高血糖素（4.8微克/千克推注加9.6微克·千克⁻¹·小时⁻¹输注）使胃松弛期间进行扩张。