黑腹果蝇的性梳减少基因有多种转录本。

The Sex combs reduced gene of Drosophila melanogaster has multiple transcripts.

作者信息

Andrew D J

机构信息

Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305-5247.

出版信息

Gene. 1995 Jan 23;152(2):149-55. doi: 10.1016/0378-1119(94)00642-6.

DOI:10.1016/0378-1119(94)00642-6

PMID:7835693

Abstract

The Sex combs reduced (Scr) homeotic gene of Drosophila melanogaster specifies the development of structures within the most posterior head segment, the labium and the most anterior thoracic segment, the prothorax or T1. Here, the structure of Scr and correct sequence of the SCR protein are presented. Scr encodes a 417-amino-acid DNA-binding protein with sequence similarity to the mouse homologues, HOXA5, B5 and C5. The greatest similarity is within the DNA-binding homeodomain (hdm); shorter conserved motifs are found near the N terminus and a region N-terminal to the hdm. As with most of the D. melanogaster homeotic genes, Scr has alternative exons.

摘要

果蝇的性梳减少（Scr）同源异型基因决定了果蝇最后端头部体节（唇叶）以及最前端胸节（前胸或T1）内结构的发育。本文展示了Scr的结构以及SCR蛋白的正确序列。Scr编码一种含有417个氨基酸的DNA结合蛋白，其序列与小鼠同源物HOXA5、B5和C5相似。最大的相似性存在于DNA结合同源结构域（hdm）内；在N端附近以及hdm的N端区域发现了较短的保守基序。与大多数黑腹果蝇同源异型基因一样，Scr有可变外显子。