Ito H, Obara T, Sasano S, Onuki T, Nitta S
Department of Surgery I, Tokyo Women's Medical College, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1994 Nov;42(11):2060-7.
Eight cases of thymic carcinoma (mean age 62 years, 5 males and 3 females) were treated in our hospital from Apr. 1988 to Mar. 1993, which were 21% of thymic epithelial tumors. The histologic subtypes of thymic carcinoma were 3 squamous, 4 undifferentiated, and 1 adenocarcinoma, respectively. Computed tomography showed extrathymic metastases to the mediastinal lymph nodes in 6 cases. All cases underwent thoracotomy, and postoperative radiotherapy or chemotherapy were performed. A case of squamous cell carcinoma in stage II who underwent total resection followed by irradiation is alive and disease free 5 years after surgery. However, the remaining 7 cases died of the disease within 29 months. 8 cases of thymic carcinoma and 7 of thymoma were studied immunohistologically on the formalin-fixed and paraffin-embedded tissues. Higher positivity of EMA in thymic carcinoma was noted comparing to ordinary thymoma, suggesting that EMA is a useful parameter of potential malignancy of the thymic epithelial neoplasms.
1988年4月至1993年3月，我院共治疗8例胸腺癌（平均年龄62岁，男5例，女3例），占胸腺上皮肿瘤的21%。胸腺癌的组织学亚型分别为3例鳞状细胞癌、4例未分化癌和1例腺癌。计算机断层扫描显示6例有纵隔淋巴结的胸腺外转移。所有病例均接受了开胸手术，并进行了术后放疗或化疗。1例Ⅱ期鳞状细胞癌患者接受了全切除并放疗，术后5年存活且无疾病。然而，其余7例在29个月内死于该病。对8例胸腺癌和7例胸腺瘤的福尔马林固定石蜡包埋组织进行了免疫组织化学研究。与普通胸腺瘤相比，胸腺癌中上皮膜抗原（EMA）的阳性率更高，提示EMA是胸腺上皮性肿瘤潜在恶性程度的一个有用参数。
