Thysman S, Hanchard C, Préat V
Université Catholique de Louvain, Ecole de Pharmacie, Unité de Pharmacie Galénique, Brussels, Belgium.
J Pharm Pharmacol. 1994 Sep;46(9):725-30. doi: 10.1111/j.2042-7158.1994.tb03891.x.
In-vitro ionotophoresis (0.33 mA cm-2) of calcitonin (50 micrograms mL-1, pH 4) was performed with the hairless rat skin model. Direct current was as potent as pulse current (2.5 kHz on/off 1/1) iontophoresis in promoting transdermal permeation of calcitonin. Increase in duration of current application from 20 min to 1 h did not increase calcitonin flux. Results suggest that calcitonin can be blocked in the skin pores through which it travels or can accumulate in the skin and be progressively released from the depot. In-vivo experiments showed that transdermal iontophoretic administration of calcitonin induced a hypocalcaemic effect in rats.
采用无毛大鼠皮肤模型进行降钙素（50微克/毫升，pH值4）的体外离子电渗疗法（0.33毫安/平方厘米）。在促进降钙素的透皮渗透方面，直流电与脉冲电流（2.5千赫开/关1/1）离子电渗疗法效果相当。将电流施加时间从20分钟增加到1小时，降钙素通量并未增加。结果表明，降钙素可能在其通过的皮肤毛孔中被阻断，或者在皮肤中蓄积并从储存库中逐渐释放。体内实验表明，降钙素的经皮离子电渗给药可在大鼠体内诱导低钙血症效应。
