Buzás G
Fövárosi Onkormányzat Balassa János Kórház és Rendelöintézet, I. Belgyógyászati Osztály.
Orv Hetil. 1994 Dec 11;135(50):2765-9.
Important role is attributed to the growth factors in the development, growth, and restitution after injury of the gastrointestinal tract. The common feature of growth factors is their ability to stimulate the growth and mitosis of quiescent cells in a nutritionally complete medium which in itself is not sufficient to initiate cell division. Epidermal growth factor prevents efficiently the experimentally induced acute gastric mucosal lesions induced by aspirin, absolute ethanol, HCl, NaCl, immobilization, and immersion and it accelerates the healing of acetic acid-induced chronic gastric and cysteamine-induced chronic duodenal ulcers. It proved to be also useful in the treatment of human gastric ulcers. Fibroblast growth factor possesses similar gastroprotective and chronic ulcer-healing properties. Its effects is much more potent than that of epidermal growth factor and that of H2-receptor blockers. The "trefoil"-peptides constitute the latest family of growth factors which are supposed to be involved in the regeneration of the normal and the ulcerated gastrointestinal mucosa. Polyamines are non-peptide growth promoting compounds present in all eukaryotic cells; their gastroprotective and ulcer-healing properties have also been published. The use of some growth factors as regenerative and angiogenic therapy could open a new, alternative way in the future management of peptic ulcer disease.
生长因子在胃肠道损伤后的发育、生长和修复过程中发挥着重要作用。生长因子的共同特点是，它们能够在营养成分齐全但本身不足以启动细胞分裂的培养基中，刺激静止细胞的生长和有丝分裂。表皮生长因子能有效预防由阿司匹林、无水乙醇、盐酸、氯化钠、制动和浸泡等实验诱导的急性胃黏膜损伤，还能加速乙酸诱导的慢性胃溃疡和半胱胺诱导的慢性十二指肠溃疡的愈合。事实证明，它对治疗人类胃溃疡也很有用。成纤维细胞生长因子具有类似的胃保护和慢性溃疡愈合特性。其效果比表皮生长因子和H2受体阻滞剂的效果要强得多。“三叶”肽是最新的一类生长因子，被认为与正常和溃疡胃肠道黏膜的再生有关。多胺是存在于所有真核细胞中的非肽类生长促进化合物；它们的胃保护和溃疡愈合特性也已见诸报道。使用某些生长因子作为再生和血管生成疗法，可能会为未来消化性溃疡疾病的治疗开辟一条新的替代途径。
