Domány G, Gere A, Paróczai M, Szántay C, Ferenczy G G, Schön I, Kiss B, Kárpáti E
Chemical Works of Gedeon Richter Ltd., Budapest, Hungary.
Pharmazie. 1994 Nov;49(11):807-10.
A series of potent inhibitors of NADPH- and Fe(2+)-dependent lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,4-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Some members of this family were effective in a bilateral carotid occlusion model in mice, and some derivatives showed protective effect in a mouse head injury model.
