Ainsworth M A, Svendsen P, Glad H, Andersen N J, Olsen O, Schaffalitzky de Muckadell O B
Dept. of Medical Gastroenterology S, Odense University Hospital, Denmark.
Scand J Gastroenterol. 1994 Oct;29(10):889-96. doi: 10.3109/00365529409094859.
The purpose of the study was to examine the effect of stimulation and inhibition of duodenal mucosal bicarbonate secretion on pancreatic and hepatic bicarbonate secretion in response to acid.
The effect of inhibition (indomethacin) or stimulation (misoprostol) of duodenal mucosal bicarbonate secretion on pancreatic and biliary bicarbonate secretion in response to intraduodenal infusion of HCl or intravenous infusion of secretin was studied in anaesthetized pigs.
The hepatic and pancreatic response to exogenous secretin was not significantly altered by stimulation/inhibition of duodenal bicarbonate secretion. However, pancreatic and biliary bicarbonate secretion in response to duodenal acidification was significantly augmented by inhibition of duodenal mucosal bicarbonate secretion; conversely, it was reduced by stimulation of duodenal bicarbonate secretion. The increase in plasma secretin levels in response to duodenal acidification was reduced by stimulation and augmented by inhibition of duodenal mucosal bicarbonate secretion.
Duodenal mucosal bicarbonate secretion can serve as a modulator of both pancreatic and biliary bicarbonate secretion in response to luminal acidification, possibly through regulation of the release of secretin.
本研究旨在探讨十二指肠黏膜碳酸氢盐分泌的刺激和抑制对胰腺和肝脏对酸刺激的碳酸氢盐分泌的影响。
在麻醉猪中，研究了十二指肠黏膜碳酸氢盐分泌的抑制（吲哚美辛）或刺激（米索前列醇）对十二指肠内注入盐酸或静脉注射促胰液素后胰腺和胆汁碳酸氢盐分泌的影响。
十二指肠碳酸氢盐分泌的刺激/抑制对外源性促胰液素引起的肝脏和胰腺反应无显著改变。然而，抑制十二指肠黏膜碳酸氢盐分泌可显著增强胰腺和胆汁对十二指肠酸化的碳酸氢盐分泌；相反，刺激十二指肠碳酸氢盐分泌则使其减少。刺激十二指肠黏膜碳酸氢盐分泌可降低十二指肠酸化引起的血浆促胰液素水平升高，而抑制则使其升高。
十二指肠黏膜碳酸氢盐分泌可能通过调节促胰液素的释放，作为胰腺和胆汁对管腔酸化的碳酸氢盐分泌的调节剂。
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