Hering W, Geisslinger G, Kamp H D, Dinkel M, Tschaikowsky K, Rügheimer E, Brune K
Department of Anaesthesiology, University of Erlangen-Nuernberg, Germany.
Acta Anaesthesiol Scand. 1994 Oct;38(7):719-23. doi: 10.1111/j.1399-6576.1994.tb03984.x.
Changes in the EEG power spectrum were studied in 50 patients (ASA status I or II), receiving either 2 mg.kg-1 of racemic ketamine or 1 mg.kg-1 of S-(+) ketamine in a randomized and double-blind manner after prior administration of 0.1 mg.kg-1 of midazolam. The patients receiving intramuscular premedication with midazolam about 45 minutes prior to induction of anaesthesia showed, in a deliberately quiet environment and mostly in the early morning, a delta dominated EEG (56% delta power) with a reduced alpha peak (17% alpha power) and an average median of 4 Hz as the baseline findings of the EEG power spectrum. The intravenous administration of midazolam led to activation of the lower beta range (13-18 Hz) and the subsequent injection of ketamine caused an increase in activity in the fast beta range (21-30 Hz), both being accompanied by a reduction of delta power from 56% to 40%. Correspondingly, an increase in the median frequency was noted. Causing nearly the same changes in EEG, S-(+) ketamine was confirmed to be twice as potent as racemic ketamine.
对50例患者（美国麻醉医师协会分级I或II级）进行了脑电图功率谱变化的研究。这些患者在预先给予0.1mg.kg-1咪达唑仑后，以随机双盲的方式接受2mg.kg-1消旋氯胺酮或1mg.kg-1 S-(+)氯胺酮。在麻醉诱导前约45分钟接受咪达唑仑肌肉注射预处理的患者，在刻意安静的环境中，且大多在清晨，脑电图以δ波为主（δ波功率占56%），α波峰值降低（α波功率占17%），脑电图功率谱的平均中位数为4Hz，作为基线表现。静脉注射咪达唑仑导致低频β波范围（13 - 18Hz）激活，随后注射氯胺酮使高频β波范围（21 - 30Hz）的活动增加，两者均伴有δ波功率从56%降至40%。相应地，中位数频率增加。S-(+)氯胺酮被证实产生与消旋氯胺酮几乎相同的脑电图变化，但其效力是消旋氯胺酮的两倍。
