Montgomery L D, Williams G B
NASA Ames Research Center Moffett Field, CA.
Aviat Space Environ Med. 1994 Nov;65(11):1005-9.
Local and sympathetic nervous system stress tests were administered prior to and following a 5-d smoking cessation program to determine the effects of short term smoking cessation upon peripheral circulation. Reactive hyperemia (RH) tests were performed on the forearm as a local dilatory stressor. Finger blood flow responses to cold pressor (CP) stresses were used to access stimulation of the sympathetic nervous system. Measures of heart rate and total forearm or finger blood flow, pulse volume and rate of blood delivery were obtained continuously during each stress test. Smoking cessation produced a significant decrease (0.01 < p < 0.05) in heart rate during both the RH and CP test sequences. Grouped mean peak forearm blood flow (Mean difference = 2.11 ml.100 ml-1.min-1; p < 0.05) and pulse volume (Mean difference = 0.04 ml.100 ml-1.pulse-1; p < 0.01) were both significantly greater following occlusion during the post-cessation RH tests than during the similar test before smoking cessation. Both finger pulse volume and rate of blood delivery were significantly greater (0.01 < p < 0.05) during the recovery portion of the post-cessation CP tests than during the same period of the pre-cessation tests. Thus, smoking cessation significantly altered both the locally mediated and central nervous system controlled responses to externally applied stressors.
在一个为期5天的戒烟计划前后进行了局部和交感神经系统应激测试，以确定短期戒烟对周围循环的影响。在前臂进行反应性充血（RH）测试，作为局部扩张应激源。利用手指对冷加压（CP）应激的血流反应来评估交感神经系统的刺激情况。在每次应激测试期间，持续获取心率、前臂或手指总血流量、脉搏容积和血液输送速率的测量值。在RH和CP测试序列中，戒烟后心率显著降低（0.01 < p < 0.05）。在戒烟后的RH测试中，阻断后分组平均前臂血流峰值（平均差异 = 2.11 ml·100 ml-1·min-1；p < 0.05）和脉搏容积（平均差异 = 0.04 ml·100 ml-1·脉搏-1；p < 0.01）均显著高于戒烟前的类似测试。在戒烟后的CP测试恢复阶段，手指脉搏容积和血液输送速率均显著高于戒烟前同一时期（0.01 < p < 0.05）。因此，戒烟显著改变了对外界施加应激源的局部介导反应和中枢神经系统控制反应。
