Tang R S
Howard Hughes Medical Institute, University of Colorado, Boulder 80302.
Bioessays. 1994 Nov;16(11):785-8. doi: 10.1002/bies.950161102.
In a recent publication, d'Alençon et al.(1) presented evidence that a form of non-homologous DNA recombination involving direct repeats is dependent upon the replication of the DNA. In addition, density-labeling experiments showed that after recombination was stimulated, progenies were present only in molecules that had undergone complete replication. These observations are consistent with a replicative and not a breakage-and-rejoining model for the DNA recombination events. These two models had of course been contrasted many years ago in mechanistic studies of homologous DNA recombination. It is therefore interesting to place the latest findings of d'Alençon et al. in this historical context.
在最近的一篇出版物中，达朗松等人（1）提出证据表明，一种涉及直接重复序列的非同源DNA重组形式依赖于DNA的复制。此外，密度标记实验表明，在重组受到刺激后，子代仅存在于经历了完全复制的分子中。这些观察结果与DNA重组事件的复制模型而非断裂-重接模型一致。当然，这两种模型在多年前同源DNA重组的机制研究中就已被对比过。因此，将达朗松等人的最新发现置于这一历史背景下是很有意思的。
