Stewart M J, Thomas G
Friedrich Miescher Institut, Basel, Switzerland.
Bioessays. 1994 Nov;16(11):809-15. doi: 10.1002/bies.950161107.
It has been known for 20 years that the ribosomal protein S6 is rapidly phosphorylated when cells are stimulated to grow or divide. Furthermore, numerous studies have documented that there is a strong correlation between increases in S6 phosphorylation and protein synthesis, leading to the idea that S6 phosphorylation is involved in up-regulating translation. In an attempt to define a mechanism by which S6 phosphorylation exerts translational control, other studies have focused on characterizing the sites of phosphorylation of this protein and its location within the ribosome. Recent data show that S6 is a protein which may have diverse cellular functions and is essential for normal development, and that it may be involved in the translational regulation of a specific class of messages.
二十年来，人们已经知道，当细胞受到刺激开始生长或分裂时，核糖体蛋白S6会迅速发生磷酸化。此外，大量研究表明，S6磷酸化的增加与蛋白质合成之间存在很强的相关性，这使得人们认为S6磷酸化参与上调翻译过程。为了确定S6磷酸化发挥翻译控制作用的机制，其他研究集中于对该蛋白的磷酸化位点及其在核糖体内的位置进行表征。最近的数据表明，S6是一种可能具有多种细胞功能且对正常发育至关重要的蛋白质，并且它可能参与一类特定信息的翻译调控。
